The diverse contexts of Indigenous settings fuel innovative solutions to research implementation problems and AIAN partnership-driven research is at the forefront of addressing methodological complexities in prevention science. Central to such innovation is authentic, sustained partnerships with community members who offer expert guidance on cultural and contextual norms and methodological logistics. Woven throughout each of the talks is the sustaining engagement and inspiration the speakers have found from the leadership of AIAN people on collaborative projects. Bidirectional co-learning, consistent with the principles of Community-Based Participatory Research (CBPR), enlivens and strengthens robust science when the insights of Indigenous community members and researchers-in-training are engaged in every phase of the research process, including problem formulation, data collection and analysis, innovative reporting of research findings, and creative feedback loops to ensure that communities reap the benefits of the information they have shared.