These federal initiatives underscore the need to sustain partnerships among researchers, practitioners, and policymakers so implementation can capitalize on evidence based interventions for substance abusing parents and their children in the CWS. This roundtable includes perspectives from Federal staff involved in conducting relevant studies and in overseeing programs that support partnerships among child welfare, family court, and substance abuse treatment services. Included are two NIDA funded researchers (along with their project officer) providing perspectives on intervention and implementation research with relevant examples of the challenges and opportunities in this complex research. One project is an RCT examining contingency management for substance abuse and the Pathways Triple P parenting program (both evidence based practices) for parents with an active CPS case who enroll in treatment for substance use disorder. The other is an intervention efficacy trial conducted in a Medicaid-only billable environment with rural, isolated or homeless populations. The project uses a range of evidence based practices to support families with substance abuse problems and CWS involvement and links to housing, employment/education and social services. Discussion foci: (a) how to ensure opportunities are increasingly available to support families and communities devastated by parental substance abuse and CWS involvement; (b) research-practice-policy partnerships are supported to facilitate the delivery, adoption, and implementation of evidence based programs/practices; and (c) identification of gaps in research, implementation and translation.