Methods: Over 500 young adult college students, oversampled for risk for substance use, were followed over three years. Data were collected on a variety of impulsivity indicators, substance use and other externalizing behavior, and psychophysiological responses to reward and punishment. Analyses were conducted to address several basic questions about the role of NU in substance use. Namely, we examined 1) the distinctiveness of NU from other impulsivity-related dimensions, 2) the incremental utility of NU in predicting a number of negative outcomes, and 3) the ability of NU to predict onset and escalation in substance use across time.
Results: Confirmatory factor analyses supported NU as a construct distinct from other impulsivity-related traits. Structural equation modeling revealed incremental predictive validity for NU in predicting a broad externalizing factor comprised of antisocial behavior, risky sex, and substance abuse. Using group-based trajectory modeling, NU was found to be related to specific trajectories of substance use across time.
Conclusions: The present results provide support for the utility and distinctiveness of NU in predicting substance use across time. Possible biological underpinnings and future prevention intervention directions will be discussed.