The present study set out to examine how salient affect may influence participant responses on TPB measures targeting marijuana use. In the current study (N = 677) participants were randomly assigned in a 2 (mood manipulation: pleasant, unpleasant) by 4 (TPB measure: attitudes, subjective norms, perceived behavioral control, intentions) between subjects factorial design. An ANCOVA revealed a significant interaction of marijuana use and mood manipulation, F (1,149) = 3.54, p = .042. Participants in the pleasant condition who reported past use reported significantly higher positive attitudes towards marijuana use than never users in the unpleasant condition and all nonusers. However, never users in the unpleasant condition reported significantly higher positive attitudes towards marijuana use than participants reporting ever use. Subjective norms analyses revealed a significant main effect of mood manipulation with participants in the pleasant condition reporting significantly more favorable subjective norms towards marijuana than participants in the unpleasant condition, F (1,170) = 1.56, p = .01. These results provide preliminary support for the hypothesis that salient mood states may significantly impact key constructs in TPB, and demonstrate the need for prevention researchers to account for context in their designs