The first presentation focuses on the level of variation in marijuana use across schools and neighborhoods using data from the National Longitudinal Study of Adolescent Health. Cross-classified multi-level logistic regression models were used to examine the relative influence of households with female head of household and owner-occupied housing. The second presentation looks as the mediating mechanisms that explain the relationship between tobacco outlet exposure and tobacco use are among emerging adults. Findings have implications for policies aimed at reducing tobacco outlet density in residential areas in order to reduce tobacco use in this population. Finally, the third presentation shifts the focus to what can occur when adolescents use substances. This paper used latent class analysis to identify subtypes of substance use among adolescents and examines the association between subtype and teen dating violence victimization. Adolescents who experienced physical and psychological victimization, as compared to those who did not, were more likely to report poly-substance use. Together, these presentations add to the growing body of research documenting the continued concern surrounding substance use among adolescents and emerging adults, while also highlighting the various avenues for intervention. At the conclusion of the presentations, the discussant will identify common themes and discuss strategies that can be used to prevent substance use. Additional suggestions for improving community and school policies and interventions for adolescents and emerging adults will be identified.