Our research at GHC concludes that item 9 (‘thoughts that you would be better off dead or of hurting yourself in some way more than half the days’ or ‘nearly every day for past two weeks’) of the PHQ depression questionnaire predicts heightened risk of suicide attempt and suicide death. Patients who score 2 or 3 on this suicide question are 5.5 times more likely to die by suicide and 9 times more likely to make a suicide attempt than individuals reporting a 0 (not at all). This conclusion is based on analysis from data linking electronic medical record, insurance claims, and death certificate data from 84,418 outpatients with PHQs (n=207,625) to suicide attempts (n=708) and suicide deaths (n=46) between 2007 and 2012. This method - the translation of basic science into prevention models - has allowed us to develop and provide more targeted interventions for high-risk individuals. We will describe the benefits and limitations of this method (improving identification of those who don’t endorse suicide ideation but who then harm themselves), as well as potential implications for public policy development.