Several models, including community-based participatory research (CPBR) (Minkler & Wallerstein, 2005), and political base building (Kellam, 2012), offer guidelines for building coalitions within communities and between communities and researchers for the purpose of studying and facilitating EBP implementation and sustainment. When studying the process of coalition building, however, perhaps the most important coalition that must be constructed involves stakeholders with a commitment to understanding this process from a research perspective and from a practitioner perspective. In this presentation, we describe this process of building a coalition involving SAMHSA policy makers, National Institute of Drug Abuse funded researchers, community leaders, and practitioners. Collectively, these groups support the development of concepts and measures that can bring precision to testing what structures and processes of community coalitions are required for implementing and sustaining EBPs while simultaneously facilitating EBP implementation and sustainment. We examine this coalition building process from the perspective of a model of cultural exchange. In this particular instance, researchers are placed in the role of culture brokers who operate within the organizational cultures of different stakeholders to identify common goals and values, negotiate aims and objectives, and implement a course of action that is supported by all involved stakeholders. These activities, in turn, produce certain “microtransformations” in the operational cultures of each stakeholder group. These microtransformations are critical to the translation of research into effective practice.